CHOLANGIOCARCINOMA DISEASE DEFINITION, PREVENTION, AND TREATMENT

CHOLANGIOCARCINOMA DISEASE DEFINITION, PREVENTION, AND TREATMENT

Understanding Cholangiocarcinoma Disease – Cholangiocarcinoma is the main meeting of the left channel of the liver to the extrahepatic bile of bile duct cancer. In clinical findings, bile duct cancer patients have symptoms of abdominal pain, bloating, skin itching, and even jaundice and other symptoms.

Cancer of the bile ducts may undergo metastasis or spread to surrounding organs. Usually, this happens in conditions that are already severe. Spread generally occurs in the liver, lung, and abdominal cavity walls.

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Diagnosis of Cholangiocarcinoma Disease

Determination of cholangiocarcinoma diagnosis can be done by the doctor through a series of medical interviews to obtain information about the symptoms and the presence of risk factors. Also, physical examination will also be done with a focus on the abdominal area.

Beyond that, it could also be needed some investigation, such as:

  • Blood test: liver function, tumor marker (CEA and CA19-9)
  • Radiology: ultrasound, CT-Scan, MRI, cholangiography
  • Laparoscopy
  • Sample biopsy

Symptoms of Illness Cholangiocarcinoma

In general, new cholangiocarcinoma symptoms appear after cancer develops to clog the bile ducts. Symptoms of this blockage include:

  • Skin and eyes look yellow (jaundice)
  • Itchy skin
  • Stools and dark colored urine
  • Loss of appetite and weight loss
  • Abdominal pain (especially upper right area) and swelling
  • High fever and chills

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Treatment of Disease Cholangiocarcinoma

The choice of cholangiocarcinoma treatment to be administered by a doctor depends on several factors of consideration. Starting from the location and the size cancer, possible side effects, the possibility of a cure, and general health conditions. Treatment options that can be pursued are:

  • Surgery
  • Radiation therapy, the use of light to kill cancer cells
  • Chemotherapy, the use of drugs to kill cancer cells
  • Palliative therapy, an attempt to control or reduce the symptoms of advanced cancer that aims to make patients not experience pain.

 

Cause of Disease Cholangiocarcinoma

Have not found the exact cause of cholangiocarcinoma. However, there are risk factors that can trigger the onset of this cancer. Risk factors include:

  • Some types of diseases of the liver and bile ducts, such as primary sclerosing cholangitis, stones or bile duct cysts, liver fluke infections, cirrhosis of the liver, hepatitis B or C
  • Inflammatory Bowel Disease (IBD)
  • exposure to thorotrast (this material was used in X-ray examinations until the 1950s)
  • alcohol consumption
  • smoke
  • obesity and diabetes

The cause of this cancer is unclear, but, chronic inflammation, bladder stones or gallbladder, bile duct disorder, bile duct, etc.; can be one factor.

  1. Chronic bile inflammation: Chronic bile inflammation can be one of the factors causing cholangiocarcinoma.
  2. Stone in the bladder/gallbladder: Approximately 20-57% of cholangiocarcinoma patients ever had a stone in the bladder/bile. Therefore, the stone in the bladder/gall can stimulate the occurrence of cholangiocarcinoma.
  3. Bile cyst duct disorder: this condition causes junction of bile ducts, and this can be one cause of cancer cholangiocarcinoma.
  4. Liver fluke: This condition is most commonly seen in Southeast Asia, mostly due to consumption of raw fish infected with liver fluke. Liver fluke usually attacks the bile duct, bile, etc. This can also be one cause of cholangiocarcinoma.

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Prevention of Disease Cholangiocarcinoma

Like most different types of cancer, cholangiocarcinoma prevention measures that can be done is not something that can be absolutely successful. Efforts to live a healthy lifestyle is the first step to maintain healthy conditions in general. Conducting periodic checks of the condition of the liver and bile can also be an attempt to prevent any larger problems from emerging.